Conclusion: There was compact relationship between thrombin or lysed RBCs and brain edema following intracerebral hemorrhage. Edema formation following thrombin infusion peaked at 24 to 72 hours, edema formation following packed RBCs infusion peaked at 96 to 120 hours. 结论:凝血酶、红细胞破解产物与实验性脑出血脑组织水肿的产生、发展关系密切,前者作用高峰期为24-72小时,后者作用高峰期为96-120小时。